Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

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Product Details :

Genre Book : Health & Fitness
Author : Robert Bazell
Editor : Random House
Release : 2011-04-27
File Download : 240 Pages
ISBN-10 : 9780307764980
Price : FREE

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Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. To improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. Current Advances in Osteosarcoma summarizes all of these new discoveries in one singular text, which will help move the field forward.

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Genre Book : Medical
Author : Eugenie S. Kleinerman, M.D.
Editor : Springer
Release : 2014-06-12
File Download : 359 Pages
ISBN-10 : 9783319048437
Price : FREE

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Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.

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Genre Book : Medical
Author : Sara Hurvitz
Editor : Elsevier Health Sciences
Release : 2018-07-26
File Download : 264 Pages
ISBN-10 : 9780323581233
Price : FREE

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Malignant pleural mesothelioma, a malignancy due largely to asbestos exposure, represents an increasingly common challenge to clinical and medical oncologists, respiratory physicians, and cardiothoracic surgeons, as well as researchers in the field. The disease has yet to reach its peak and is expected to kill over 100,000 people worldwide. As malignant pleural mesothelioma gains in profile, Kenneth O'Byrne and Valerie Rusch present a comprehensive overview of the subject, aimed at all health care professionals who come into contact with patients with the disease. The book includes chapters on epidemiology, diagnosis, histopathology, radiology, surgery, chemotherapy, immune therapy, radiotherapy, and palliative medicine, written by an international team of contributors. A molecular biology section focuses on the carcinogenic effects of asbestos fibres and simian virus 40, angiogenesis and angiogenic growth factors, the immune response, and genetic abnormalities detected inthe disease. Future therapies are also covered, as is a perspective on the distinct legal issues related to the disease. This highly-illustrated, full colour book provides the ultimate, timely resource on this devastating disease.

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Genre Book : Medical
Author : Ken O'Byrne
Editor : Oxford University Press, USA
Release : 2006
File Download : 464 Pages
ISBN-10 : 0198529309
Price : FREE

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WILLMINGTON'S GUIDE TO THE BIBLE is a treasury of Bible knowledge written in layman's language. Dr. Willmington's goal has been to publish a concise, all-inclusive summary of basic Bible information in one volume, to make available in abbreviated form "a complete Bible education in a single book.

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Product Details :

Genre Book : Religion
Author : H. L. Willmington
Editor : Tyndale House Publishers, Inc.
Release : 1981
File Download : 1006 Pages
ISBN-10 : 0842388044
Price : FREE

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HER2 Inhibitors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built HER2 Inhibitors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of HER2 Inhibitors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

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Genre Book : Medical
Author :
Editor : ScholarlyEditions
Release : 2013-06-21
File Download : 77 Pages
ISBN-10 : 9781481676236
Price : FREE

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Finding Home Series: Cry of the West: Hallie Rescue on the Rio: Lilah Missouri Challenge: Daisy Rush Garrett has been hired by his friends, Cooper and Hallie Jerome (book one), to find Hallie's sister, Lilah, and persuade her to return to Oregon with him. The sisters parted ways twenty years earlier and Hallie longs to be reunited with her only sibling. Lilah Parker yearns for her family, but in her infrequent letters to her sister Hallie, she has lied about her occupation. Her sister believes her to be a seamstress, when, in truth, she is a wealthy man's mistress. Lilah's shame and fear that she will be disowned by her loved ones causes her to reject Rush's offer of escort to Oregon. However, fate has other plans for these mismatched lovers as they travel from New Orleans to the Willamette Valley in Oregon. Oh, and along the way, Lilah gets kidnapped by bandits. The book can be read as a standalone.

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Genre Book : Fiction
Author : Verna Clay
Editor : M.O.I. Publishing
Release : 2013-05-27
File Download : 243 Pages
ISBN-10 :
Price : FREE

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Genre Book :
Author :
Editor : Pearson Education India
Release :
File Download : Pages
ISBN-10 : 8131763048
Price : FREE

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Genre Book :
Author : Alexander Cruden
Editor :
Release : 1820
File Download : Pages
ISBN-10 : OXFORD:590274331
Price : FREE

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More Heart-Gripping Fiction From Bestselling Author Linda Nichols A girl who has never been able to settle down, Miranda begins various adventures, but whenever reality begins to tarnish her dreams, she gives up. As she approaches her twenty-seventh birthday, she determines to reinvent her life. But there's one loose end to tie down first... Joseph Williams, the chief of police in Abingdon, Virginia, always tries to do what is right, to perform his duty and protect those he loves. He becomes suspicious of the new woman in town, and after checking further, he discovers she has no history. Then he finds a baby picture of his niece in her possession... In Search of Eden is a story about law and grace, about forgiveness and redemption, about finding joy and rest in a broken world.

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Product Details :

Genre Book : Fiction
Author : Linda Nichols
Editor : Baker Books
Release : 2007-02-01
File Download : 448 Pages
ISBN-10 : 9781441260291
Price : FREE

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